385 Parkinsonism Induced by Chronic Manganese Intoxication – An Experience in Taiwan

نویسندگان

  • Chang Gung
  • Han-Yi Wang
  • Chin-Chang Huang
چکیده

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Parkinsonism induced by chronic manganese intoxication--an experience in Taiwan.

Excessive manganese exposure may induce a neurological syndrome called manganism, which is similar to Parkinson's disease (PD). However, close observation of patients with manganism reveals a clinical disease entity different from PD, not only in the clinical manifestations, but also in therapeutic responses, in neuroimaging studies such as magnetic resonance imaging, positron emission tomograp...

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INTRODUCTION Manganese regulates many enzymes and is essential for normal development and body function. Chronic manganese intoxication has an insidious and progressive course and usually starts with complaints of headache, fatigue, sleep disturbances, irritability and emotional instability. Later, several organ systems may be affected and, due to neurotoxicity, an atypical parkinsonian syndrom...

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Manganese induced parkinsonism: a case report.

Manganese (Mn) intoxication is known to induce parkinsonism. Mn-induced parkinsonism preferentially affect the globus pallidus in contrast to idiopathic parkinsonism where degeneration predominantly involves the nigral pars compacta. We describe a 51-year-old man who had been occupationally exposed to Mn. He had parkinsonian features including masked face, resting tremor, and bradykinesia. He a...

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تاریخ انتشار 2007